Behavioral changes in FPR2/ALX and Chemr23 receptor knockout mice are exacerbated by prenatal alcohol exposure

نویسندگان

چکیده

Introduction Prenatal alcohol exposure (PAE) causes neuroinflammation that may contribute to the pathophysiology underlying Fetal Alcohol Spectrum Disorder. Supplementation with omega-3 polyunsaturated fatty acids (PUFAs) has shown success in mitigating effects of PAE animal models, however, mechanisms are unknown. Some PUFA metabolites, specialized pro-resolving mediators (SPMs), play a role resolution phase inflammation, and receptors for these brain. Methods To test hypothesis SPM FPR2 ChemR23 PAE-induced behavioral deficits, we exposed pregnant wild-type (WT) knockout (KO) mice late gestation behaviorally tested male female offspring as adolescents young adults. Results Maternal fetal outcomes were not different among genotypes, growth phenotypes did differ unique each line. In absence PAE, KO animals showed decreased anxiety-like behavior on elevated plus maze had poor grip strength low activity compared age-matched WT mice. improved performance fear conditioning between adolescence adulthood, this was seen either KO. Discussion This model subtle lower levels adults, males ages, response cue indicating an effect learning. The PAE-mediated also but mice, worsened adolescent activity. Collectively, findings provide mechanistic insight into how PUFAs could act attenuate cognitive impairments caused by PAE.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Methamphetamine- and 3,4-methylenedioxymethamphetamine-induced behavioral changes in histamine H3-receptor knockout mice.

Histamine H(3) receptors inhibit the release of not only histamine itself, but also other neurotransmitters including dopamine. Previous papers have reported that histaminergic neurons inhibit psychostimulant-induced behavioral changes. To examine whether deficiency in histamine H(3) receptors influences psychostimulant-induced behavioral sensitization and reward, we examined locomotor activity...

متن کامل

Prenatal Exposure to Alcohol

Fetal Alcohol Syndrome (FAS) is a set of birth defects caused by maternal consumption of alcohol during pregnancy. At birth, children with FAS can be recognized by growth deficiency and a characteristic set of minor facial traits that tend to become more normal as the child matures. Less evident at birth—but far more devastating to FAS children and their families—are the lifelong effects of alc...

متن کامل

Prenatal Exposure to Alcohol

Maternal alcohol consumption during pregnancy can cause serious birth defects, of which fetal alcohol syndrome (FAS) is the most devastating. Recognizable by characteristic craniofacial abnormalities and growth deficiency, this condition includes severe alcohol-induced damage to the developing brain. FAS children experience deficits in intellectual functioning; difficulties in learning, memory,...

متن کامل

Androgens and prenatal alcohol exposure.

4. T. L. Harvey and D. E. Howell, J. Econ. Entomol. 7, 92 (1965). 5. Insects were collected from infested bins as larvae or pupae in strips of corrugated paper placed on the grain surface. The paper containing insects was returned to the laboratory and placed in jars, where adults emerged. Eggs were collected from these adults and used to start colonies on the standard laboratory larval diet of...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Frontiers in Neuroscience

سال: 2023

ISSN: ['1662-453X', '1662-4548']

DOI: https://doi.org/10.3389/fnins.2023.1187220